| Simulator: copasi 4.36.260 | |
| CPU cores: 1 | |
| RAM: 8 GB | |
| Max time: 20 m |
| Submitted: 2023-06-02 08:04:49 PM | |
| Updated: 2023-06-02 08:05:22 PM | |
Status: Succeeded |
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10.36 KB
123 B
2.140 KB
28.08 KB
44.66 KB
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121.0 KB
7.627 KB
30.68 KB
89.63 KB
Name
Format
Download
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N/A
40.86 KB
N/A
This model presents a general target-mediated drug disposition (TMDD) model for bispecific antibodies (BsAbs), which bind to two different targets on different cell membranes. The model includes four different binding events for BsAbs, turnover of the targets, and internalization of the complexes. In addition, a quasi-equilibrium (QE) approximation with decreased number of binding parameters is also present.