| Simulator: tellurium 2.2.8 | |
| CPU cores: 1 | |
| RAM: 8 GB | |
| Max time: 20 m |
| Submitted: 2023-05-26 07:31:55 PM | |
| Updated: 2023-05-26 07:32:34 PM | |
Status: Succeeded |
This sbml file describes the RECI model from:
<br/>
"Mathematical modeling identifies Smad nucleocytoplasmic shuttling as a dynamic signal-interpreting system" by Bernhard Schmierer, Alexander L. Tournier, Paul A. Bates and Caroline S. Hill, Proc Natl Acad Sci U S A. 2008 May 6;105(18):6608-13.
<br/>
All parameter and species names are as in Figure S3 of the original publication. The original model was done in copasi.
<br/>
SB-431542 addition to a concentration of 10000 nM is set at 2700 sec. The initial concentration of SB, the time point of addition and the final concentration can be set by altering the parameters
<b>SB_0</b>,
<b>t_SB</b> and
<b>SB_end</b>.
<br/>
This model file has been used to reproduce Figures 2D and 5A from the research paper using SBMLodesolver. To get the results for the figures, sum the corresponding concentrations:
<br/>
fig 2D: nuclear EGFP-Smad2 = G_n + pG_n + G2_n + G4_n + 2* GG_n
<br/>
fig 5A (either n or c for nucleus or cytosol):
<br/>
monomeric Smad2 = S2_n/c + G_n/c
<br/>
monomeric P-Smad2 = pS2_n/c + pG_n/c
<br/>
Smad2/Smad4 complexes = S24_n/c + G4_n/c
<br/>
Smad2/Smad2 complexes = S22_n/c + G2_n/c + GG_n/c
<br/></p>
<p>This model originates from BioModels Database: A Database of Annotated Published Models. It is copyright (c) 2005-2009 The BioModels Team.
<br/>For more information see the
<a href="http://www.ebi.ac.uk/biomodels/legal.html" target="_blank">terms of use</a>.
<br/>To cite BioModels Database, please use
<a href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=16381960" target="_blank"> Le Novère N., Bornstein B., Broicher A., Courtot M., Donizelli M., Dharuri H., Li L., Sauro H., Schilstra M., Shapiro B., Snoep J.L., Hucka M. (2006) BioModels Database: A Free, Centralized Database of Curated, Published, Quantitative Kinetic Models of Biochemical and Cellular Systems Nucleic Acids Res., 34: D689-D691.</a></p>
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