| Simulator: copasi 4.36.260 | |
| CPU cores: 1 | |
| RAM: 8 GB | |
| Max time: 20 m |
| Submitted: 2023-05-26 07:29:21 PM | |
| Updated: 2023-05-26 07:29:53 PM | |
Status: Succeeded |
The model is described in the paper by Wu and Chang (2006). Diethyl pyrocarbonate, a histidine-modifying agent, directly stimulates activity of ATP-sensitive potassium channels in pituitary GH3 cells. Biochem Pharmacol. 71(5): 615-23.
The unit of time is ms, and the simulation time is 80 s, that is 8e4 ms. Therfore, you probably need to increase the maximum steps for your simulator.
The figure 7 has been reproduced by MathSBML. Application of DEPC as indicated at horizontal bar was mimicked by an increase of maximal conductance of Katp-channels from 500 to 530 ps at t=30 s.
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