Can yeast glycolysis be understood in terms of in vitro kinetics of the constituent enzymes? Testing biochemistry.
Teusink,B et al.: Eur J Biochem 2000 Sep;267(17):5313-29.
The model reproduces the steady-state fluxes and metabolite concentrations of the branched model as given in Table 4 of the paper. It is derived from the model on JWS online, but has the ATP consumption in the succinate branch with the same stoichiometrie as in the publication. The model was successfully tested on copasi v.4.4(build 26).
For Vmax values, please note that there is a conversion factor of approx. 270 to convert from U/mg-protein as shown in Table 1 of the paper to mmol/(min*L_cytosol). The equilibrium constant for the ADH reaction in the paper is given for the reverse reaction (Keq = 1.45*10 ⁴ ). The value used in this model is for the forward reaction: 1/Keq = 6.9*10 ^-5 .
Vmax parameters values used (in [mM/min] except VmGLT):

1. the species a should denote NAD and b Ethanol
2. the last term in the equation should read bpq /( K _ib K _iq K _p )

1. R = 1 + λ ₁ + λ ₂ + g _r λ ₁ λ ₂
2. equation L should read: L = L0*(..) ² *(..) ² *(..) ² not L = L0*(..) ² *(..) ² *(..)

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