Model Status

This model runs in OpenCell and COR and the units are consistent throughout. It it an accurate reproduction of the paper equations but does not reproduce the published results for unknown reasons, possibly because initial conditions for state variables were guessed.

Model Structure

ABSTRACT: We investigate bursting behaviour generated in an electrophysiological model of pituitary corticotrophs. The active and silent phases of this mode of bursting are generated by moving between two stable oscillatory solutions. The bursting is indirectly driven by slow modulation of the endoplasmic reticulum Ca2+ concentration. The model exhibits different modes of bursting, and we investigate mode transitions and similar modes of bursting in other Hodgkin-Huxley models. Bifurcation analysis and the use of null-surfaces facilitate a geometric interpretation of the model bursting modes and action potential generation, respectively.

The original paper reference is cited below:

A Hodgkin-Huxley Model Exhibiting Bursting Oscillations, Paul R. Shorten and David J.N. Wall, 2000, Bulletin of Mathematical Biology, 62, 695-715. PubMed ID: 10938629