The XPPAUT code for the paper:

Y.Liu, J. Milton and S.A. Campbell (2019)
Outgrowing seizures in Childhood Absence Epilepsy: time delays and bistability Journal of Computational Neuroscience, doi:10.1007/s10827-019-00711-x.

Details on installing XPPAUT can be found on Bard Ermentrout's XPPAUT webpage.

To reproduce figures in paper, all parameters can be left at default values: (Initialconds -> Go)

except as follows.

Figure 2: (use Parameters menu, type variable name, value) (type escape key "esc" when done/ready to run the model) gd_AMPA=0,ge_AMPA=0. Left: Itc_ext_c=5;

Right: Itc_ext_c=6 Top gb_GABAA=0.6;

Bottom: gb_GABAA=0.1 Middle gb_GABAA=0.3; Figure 3: gd_AMPA=0,ge_AMPA=0. Itc_ext_c=5, Itc_pert=1.5, ontime=2000, offtime=2500 Left gb_GABAA=0.1; Middle gb_GABAA=0.4; Right: gb_GABAA=0.7

Figure 4: Itc_ext=5, tau1=9, tau2=2.8 Top left gb_GABAA=0.6; Top right gb_GABAA=0.1; Bottom left: gb_GABAA=0.29; Bottom right: gb_GABAA=0.2;

Figure 5: Itc_ext_c=5, tau2=2.8 Left gb_GABAA=0.6, tau1=4.2 Right gb_GABAA=0.5, tau1=8.4

Figure 6: Itc_ext_c=5, tau2=2.8, Itc_pert=1, ontime=2000, offtime=2300 Left gb_GABAA=0.7; Right: gb_GABAA=0.4 Top tau1=8.4; Bottom: tau1=2.8

To modify the initial conditions for Figure 6 as described on page 7 of the paper, use the "delay ICs" window in XPPAUT.