| Simulator: xpp 8.0 | |
| CPU cores: 1 | |
| RAM: 8 GB | |
| Max time: 20 m |
| Submitted: 2022-02-28 09:46:37 PM | |
| Updated: 2022-02-28 09:47:44 PM | |
Status: Succeeded |
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This model includes ion concentration dynamics (sodium, potassium, chloride) inside and outside the neuron, the exchange of ions with glia and blood vessels, volume dynamics of neuron, glia, and extracellular space, glutamate homeostasis involving release by neuron and uptake by both neuron and glia. Spreading depolarization is used as a case study.
This is the readme for the AUTO models associated with the paper:
Hübel N, Hosseini-Zare MS, Žiburkus J, Ullah G (2017) The role of glutamate in neuronal ion homeostasis: A case study of spreading depolarization. PLoS Comput Biol 13:e1005804
http://dx.doi.org/10.1371/journal.pcbi.1005804
The model file was contributed by G Ullah, and requires XPP/AUTO which is freely available here: http://www.math.pitt.edu/~bard/xpp/xpp.html
To run:
On unix/linux start with a command like:
xppaut SD.ode
Click on Initialconds -> Go.
After a short time you should see the following graph similar to figure 2a in the paper
