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| Submitted: 2022-02-28 09:46:31 PM | |
| Updated: 2022-02-28 09:48:41 PM | |
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In this paper, we demonstrate how dorsal root ganglion (DRG) neuron excitability can become pathologically altered, as occurs in neuropathic pain. Specifically, we reproduce pathological changes in spiking pattern (from transient to repetitive spiking) and the development of membrane potential oscillations and bursting.
This is the readme for the models associated with the paper:
Rho YA, Prescott SA (2012) Identification of molecular pathologies sufficient to cause neuropathic excitability in primary somatosensory afferents using dynamical systems theory. PLoS Comput Biol 8:e1002524
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