PreBotzinger Complex inspiratory neuron with NaP and CAN currents (Park and Rubin 2013)
Project Description
We have built on earlier models to develop a single-compartment Hodgkin-Huxley type model incorporating NaP and CAN currents, both of which can play important roles in bursting of inspiratory neurons in the PreBotzinger Complex of the mammalian respiratory brain stem. The model tracks the evolution of membrane potential, related (in)activation variables, calcium concentration, and available fraction of IP3 channels. The model can produce several types of bursting, presented and analyzed from a dynamical systems perspective in our paper.
Jonathan E Rubin
Choongseok Park
This is the readme for the model associated with the paper
Park C, Rubin JE (2013) Cooperation of intrinsic bursting and calcium
oscillations underlying activity patterns of model pre-Botzinger
complex neurons. J Comput Neurosci 34:345-66
This model written in XPP was implemented by Jon Rubin and Choongseok
Park.
To run the model in it's default setting start with a command like
(depends on your platform):
xppaut OneCellTwoOsc.ode
Once XPP starts select Initalconds -> (G)o to see an figure like this:
Inside XPP, use File -> Read set with the included set files to get
certain dynamics from the paper:
OneCellTwoOsc.ode.setsb the paper's Fig. 2a,
OneCellTwoOsc.ode.setdb the paper's Fig. 2b,
OneCellTwoOsc.ode.setsdb the paper's Fig. 2c
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fig2a.png
Portable Network Graphics (PNG)
fig2b.png
fig2c.png
metadata.rdf
OMEX Metadata
OneCellTwoOsc.ode
XPP
OneCellTwoOsc.ode.setdb
XPP_SET
OneCellTwoOsc.ode.setsb
OneCellTwoOsc.ode.setsdb
OneCellTwoOsc.sedml
Simulation Experiment Description Markup Language (SED-ML)
readme.html
Hypertext Markup Language (HTML)
screenshot.png
Outputs
JavaScript Object Notation (JSON) in BioSimulators simulator schema
Zip of HDF5 and PDF files
Log
JavaScript Object Notation (JSON) in BioSimulators log schema