Morphogenesis checkpoint in budding yeast (continuous) (Ciliberto et al., J Cell Biol, 2003)
Project Description
Continuous kinetic model of the molecular network that controls Swe1 and the regulation of cyclin-dependent kinase.
Andrea Ciliberto
Bela Novak
John J. Tyson
Set of ordinary differential equations that model the molecular network that controls Swe1 and the regulation of cyclin-dependent kinase. The model is based on published observations of budding yeast and analogous control signals in fission yeast. Simulations of the model accurately reproduce the phenotypes of a dozen checkpoint mutants. Among other predictions, the model attributes a new role to Hsl1, a kinase known to play a role in Swe1 degradation: Hsl1 must also be indirectly responsible for potent inhibition of Swe1 activity. The model supports the idea that the morphogenesis checkpoint, like other checkpoints, raises the cell size threshold for progression from one phase of the cell cycle to the next.
Privacy settings
To improve your experience with BioSimulations, we use cookies to store information about your preferences and to track your use of the site. This information does not identify you personally or preserve personal information about you. This allows us to improve the site and gather usage information for funding and development. Because we respect your right to privacy, you can opt-out of this data.
BioSimulations collects limited personal data to credit authors and improve the platform. By using this site, you agree to our terms of service, privacy policy, and use of cookies.
Browse simulation projects
Browse simulator tools
Browse the docs
Re-run Original Simulation
Customize & Re-run Simulation
Project
Download File
Open Modeling and Exchange (OMEX)
BIOMD0000000297_url.xml
Systems Biology Markup Language (SBML)
expected-results.json
JavaScript Object Notation (JSON)
Figure1.jpg
Joint Photographic Experts Group (JPEG)
Figure2.jpg
Figure3.vg.json
Vega
metadata.rdf
OMEX Metadata
reports.h5
Hierarchical Data Format 5 (HDF5)
simulation_1.sedml
Simulation Experiment Description Markup Language (SED-ML)
Outputs
JavaScript Object Notation (JSON) in BioSimulators simulator schema
Zip of HDF5 and PDF files
Log
JavaScript Object Notation (JSON) in BioSimulators log schema