| Simulator: ginsim 3.0.0b | |
| CPU cores: 1 | |
| RAM: 8 GB | |
| Max time: 20 m |
| Submitted: 2022-02-05 04:23:34 PM | |
| Updated: 2022-02-05 04:24:16 PM | |
Status: Succeeded |
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Qualitative model of the EGF and TNFα signaling pathways.
- Claudine Chaouiya
- Duncan Bérenguier
- Sarah M Keating
- Aurélien Naldi
- Martijn P van Iersel
- Nicolas Rodriguez
- Andreas Dräger
- Finja Büchel
- Thomas Cokelaer
- Bryan Kowal
- Benjamin Wicks
- Emanuel Gonçalves
- Julien Dorier
- Michel Page
- Pedro T Monteiro
- Axel von Kamp
- Ioannis Xenarios
- Hidde de Jong
- Michael Hucka
- Steffen Klamt
- Denis Thieffry
- Nicolas Le Novère
- Julio Saez-Rodriguez
- Tomáš Helikar
Qualitative model of the EGF and TNFα signaling pathways which captures how EGF and TNFα ligands stimulate ERK, JNK and p38 MAPK cascades, the PI3K/AKT pathways, and the NFκB cascade. In addition, the model encompasses cross-talks between these pathways, as well as two negative feedback loops: one in the NFκB cascade and one in the MAPK cascade.